Cushing Syndrome Induced by Topical Corticosteroids for the Treatment of Lichen Sclerosus

Manisha Notay; Nasim Fazel; Smita Awasthi

doi:10.1016/j.jpag.2018.09.004

Cushing Syndrome Induced by Topical Corticosteroids for the Treatment of Lichen Sclerosus

J Pediatr Adolesc Gynecol. 2019 Feb;32(1):83-85. doi: 10.1016/j.jpag.2018.09.004. Epub 2018 Sep 20.

Authors

Manisha Notay¹, Nasim Fazel¹, Smita Awasthi²

Affiliations

¹ Department of Dermatology, University of California, Davis, Sacramento, California.
² Department of Dermatology, University of California, Davis, Sacramento, California; Department of Pediatrics, University of California, Davis, Sacramento, California. Electronic address: sawasthi@ucdavis.edu.

PMID: 30244192
DOI: 10.1016/j.jpag.2018.09.004

Abstract

Background: Lichen sclerosus is a chronic inflammatory dermatological condition with a predilection for the anogenital area.

Case: We describe a case of iatrogenic Cushing syndrome from the administration of high-potency topical steroids for vulvar lichen sclerosus in a 6-year-old girl. Her symptoms resolved after the cessation of topical steroid treatment.

Summary and conclusion: This case brings attention to iatrogenic Cushing syndrome as a potential complication when using high-potency topical corticosteroids in the anogenital region.

Keywords: Cushing syndrome; Lichen sclerosus; Pediatric; Topical steroids.

MeSH terms

Administration, Topical
Child
Clobetasol / administration & dosage
Clobetasol / adverse effects*
Cushing Syndrome / chemically induced*
Cushing Syndrome / diagnosis
Female
Glucocorticoids / administration & dosage
Glucocorticoids / adverse effects*
Humans
Vulvar Lichen Sclerosus / drug therapy*

Substances

Glucocorticoids
Clobetasol