Synthesis of 28,28,28-trideutero-25-hydroxydihydrotachysterol2

J Steroid Biochem Mol Biol. 2019 Jan:185:248-250. doi: 10.1016/j.jsbmb.2018.09.014. Epub 2018 Sep 19.

Abstract

As part of our program on synthesis of labeled vitamin D metabolites and analogs, we describe here an efficient and versatile synthetic approach to 28,28,28-trideutero- 25-hydroxydihydrotachysterol2 where isotopic labeling was incorporated stereoselectively in the last step of the synthesis. This deuterated compound will allow the study this analog in vitro or in vivo and to measure AT10-like compounds in serum by LC-MS/MS.

Keywords: 25-Hydroxydihydrotachysterol(2); Labeled compounds; Synthesis; Vitamin D.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Deuterium / chemistry
  • Dihydrotachysterol / analogs & derivatives*
  • Dihydrotachysterol / analysis*
  • Dihydrotachysterol / chemical synthesis
  • Dihydrotachysterol / chemistry*
  • Staining and Labeling
  • Vitamin D / analogs & derivatives*
  • Vitamin D / chemistry
  • Vitamin D / metabolism*

Substances

  • Vitamin D
  • 25-hydroxydihydrotachysterol(2)
  • Deuterium
  • Dihydrotachysterol