Discovery of highly insecticidal synthetic spinosyn mimics - CAMD enabled de novo design simplifying a complex natural product

Thomas C Sparks; Gary D Crouse; David A Demeter; Geno Samaritoni; Casandra L McLeod

doi:10.1002/ps.5217

Discovery of highly insecticidal synthetic spinosyn mimics - CAMD enabled de novo design simplifying a complex natural product

Pest Manag Sci. 2019 Feb;75(2):309-313. doi: 10.1002/ps.5217. Epub 2018 Oct 30.

Authors

Thomas C Sparks¹, Gary D Crouse¹, David A Demeter¹, Geno Samaritoni¹, Casandra L McLeod¹

Affiliation

¹ Corteva Agriscience™, Agriculture Division of DowDuPont™, Dow AgroSciences, Discovery Research, Indianapolis, IN, USA.

PMID: 30242953
DOI: 10.1002/ps.5217

Abstract

Simplifying complex natural products: Computer modeling-based design leads to highly insecticidal, chemically simpler synthetic mimics of the spinosyn natural products that are active in the field. © 2018 Society of Chemical Industry.

Keywords: insecticide discoverymacrolidesynthetic; mimics; natural product; spinosyn.

MeSH terms

Biological Products / analysis*
Computer Simulation
Drug Design*
Insecticides / analysis*
Macrolides / analysis*

Substances

Biological Products
Insecticides
Macrolides