Control Strategies in Multigroup Models: The Case of the Star Network Topology

Bull Math Biol. 2018 Nov;80(11):2978-3001. doi: 10.1007/s11538-018-0503-6. Epub 2018 Sep 21.

Abstract

In this paper, we propose control strategies for multigroup epidemic models. We use compartmental [Formula: see text] models to study the dynamics of n host groups sharing the same source of infection in addition to the transmission among members of the same group. In particular, we consider a model for infectious diseases with free-living pathogens in the environment and a metapopulation model with a central patch. We give the detailed derivation of the target reproduction number under three public health interventions and provide the corresponding biological insights. Moreover, using the next-generation approach, we calculate the basic reproduction numbers associated with subsystems of our models and determine algebraic connections to the target reproduction number of the complete model. The analysis presented here illustrates that understanding the topological structure of the infection process and partitioning it into simple cycles is useful to design and evaluate the control strategies.

Keywords: Basic reproduction number; Control strategies; Multigroup model; Star network; Target reproduction number.

MeSH terms

  • Animals
  • Bacterial Shedding
  • Basic Reproduction Number / statistics & numerical data
  • Communicable Disease Control / statistics & numerical data
  • Communicable Diseases / epidemiology*
  • Communicable Diseases / transmission
  • Computer Simulation
  • Disease Reservoirs / statistics & numerical data
  • Environmental Microbiology
  • Epidemics / prevention & control*
  • Host Microbial Interactions
  • Host-Pathogen Interactions
  • Humans
  • Leptospira / pathogenicity
  • Leptospirosis / epidemiology
  • Leptospirosis / prevention & control
  • Leptospirosis / transmission
  • Mathematical Concepts
  • Models, Biological*
  • Risk Factors