Mallostery: Filling a niche between quality and metabolic control

Ngee Kiat Chua; Andrew J Brown

doi:10.1074/jbc.H118.005031

Mallostery: Filling a niche between quality and metabolic control

J Biol Chem. 2018 Sep 21;293(38):14951-14952. doi: 10.1074/jbc.H118.005031.

Authors

Ngee Kiat Chua¹, Andrew J Brown²

Affiliations

¹ From the School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia.
² From the School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia aj.brown@unsw.edu.au.

Abstract

To be, or not to be … What determines the destruction of a protein in response to metabolic cues? In the current issue of JBC, Wangeline and Hampton shed new light on this existential question by studying the classic case of HMGCR (Hmg2 in yeast), the rate-limiting step in sterol synthesis, and find a metabolic cue that causes "allosteric misfolding" and subsequent destruction of the protein, a concept they name mallostery.

Publication types

Comment

MeSH terms

Hydroxymethylglutaryl CoA Reductases*
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins*
Sterols

Substances

Saccharomyces cerevisiae Proteins
Sterols
HMG2 protein, S cerevisiae
Hydroxymethylglutaryl CoA Reductases