Abstract
Two recent studies implicate PARP as sensors of incompletely processed Okazaki fragments, changing our view about how single-strand breaks arise in unperturbed cells. Unligated Okazaki fragments may trigger homologous recombination-mediated repair and underpin genome instability in BRCA1/BRCA2-deficient cancers.
Published by Elsevier Inc.
MeSH terms
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BRCA1 Protein / genetics
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BRCA2 Protein / genetics
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Breast Neoplasms*
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DNA
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DNA Repair
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DNA Replication
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Humans
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Poly(ADP-ribose) Polymerase Inhibitors
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Poly(ADP-ribose) Polymerases*
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Synthetic Lethal Mutations
Substances
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BRCA1 Protein
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BRCA2 Protein
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Okazaki fragments
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Poly(ADP-ribose) Polymerase Inhibitors
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DNA
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Poly(ADP-ribose) Polymerases