Bypassing Kinase Signaling in Mammalian Cells

Cell Chem Biol. 2018 Sep 20;25(9):1051-1053. doi: 10.1016/j.chembiol.2018.09.001.

Abstract

Serine phosphorylation is frequently used to control the activity of proteins. Eukaryotic cells employ cascades of these phosphorylation events to encode and distribute information. In this issue of Cell Chemical Biology, Beránek et al. (2018) report the creation of a system to genetically incorporate phosphoserine in mammalian cells, thereby circumventing upstream kinase signaling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Phosphorylation
  • Phosphoserine
  • Serine*
  • Signal Transduction*

Substances

  • Phosphoserine
  • Serine