Design and synthesis of novel 6-substituted quinazoline-2-thiols

Satya Karuna Pulakhandam; Naresh Kumar Katari; Sreekantha B Jonnalagadda

doi:10.1007/s11030-018-9874-8

Design and synthesis of novel 6-substituted quinazoline-2-thiols

Mol Divers. 2019 May;23(2):351-360. doi: 10.1007/s11030-018-9874-8. Epub 2018 Sep 20.

Authors

Satya Karuna Pulakhandam¹, Naresh Kumar Katari^{2

3}, Sreekantha B Jonnalagadda⁴

Affiliations

¹ Jawaharlal Nehru Technological University Kakinada, Kakinada, Andhra Pradesh, 533 003, India.
² Department of Chemistry, GITAM School of Technology, GITAM Deemed to be University, HTP Campus, Rudraram, Medak, Telangana, 502 329, India. dr.n.k.katari@gmail.com.
³ School of Chemistry and Physics, University of KwaZulu-Natal, P Bag X 54001, Durban, 4000, South Africa. dr.n.k.katari@gmail.com.
⁴ School of Chemistry and Physics, University of KwaZulu-Natal, P Bag X 54001, Durban, 4000, South Africa. jonnalagaddas@ukzn.ac.za.

PMID: 30238392
DOI: 10.1007/s11030-018-9874-8

Abstract

A novel design and efficient protocol for the synthesis of new class of 6-substituted quinazoline-2-thiols is reported. The derivatization of the thioquinazolines is achieved in a strategic manner using 2-aminobenzylamine. The functionalization of the aniline followed by construction of the heterocyclic ring provides a facile way to synthesize these bifunctional quinazolines.

Keywords: 2-Aminobenzylamine; 6-Substituted-2-thioquinazolines; Aromatic substitution; Boc protection; Dithiocarbamate.

MeSH terms

Benzylamines / chemistry
Drug Design
Quinazolines / chemistry*
Sulfhydryl Compounds / chemistry*

Substances

Benzylamines
Quinazolines
Sulfhydryl Compounds