The evolutionary hypothesis of reaction specificity of mammalian ALOX15 orthologs

Prog Lipid Res. 2018 Oct:72:55-74. doi: 10.1016/j.plipres.2018.09.002. Epub 2018 Sep 17.

¹ Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Biochemistry, Charitéplatz 1, CCO- Building, Virchowweg 6, D-10117 Berlin, Germany. Electronic address: hartmut.kuehn@charite.de.
² Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Biochemistry, Charitéplatz 1, CCO- Building, Virchowweg 6, D-10117 Berlin, Germany.
³ Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Internal Medicine, Division of Hepathology and Gastroenterology, Augustenburger Platz 1, D-13353 Berlin, Germany.

No abstract available

Keywords: Coagulation; Eicosanoids; Enzyme evolution; Inflammation; Lipoxygenase pathway; Mammals.

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