Biological role of miR-204 and miR-211 in melanoma

Marianna Vitiello; Romina D'Aurizio; Laura Poliseno

doi:10.18632/oncoscience.443

Biological role of miR-204 and miR-211 in melanoma

Oncoscience. 2018 Aug 22;5(7-8):248-251. doi: 10.18632/oncoscience.443. eCollection 2018 Jul.

Authors

Marianna Vitiello^{1

2}, Romina D'Aurizio³, Laura Poliseno^{1

2}

Affiliations

¹ Oncogenomics Unit, CRL-ISPRO, 56124 Pisa, Italy.
² Institute of Clinical Physiology, CNR, 56124 Pisa, Italy.
³ Institute of Informatics and Telematics, CNR, 56124 Pisa, Italy.

Abstract

In this short report, we pinpoint some technical and conceptual flaws that we found in the article entitled "miR-204-5p and miR-211-5p contribute to BRAF inhibitor resistance in melanoma" (Díaz-Martínez et al., Cancer Research 2018). We also discuss how, in our opinion, these flaws led Díaz-Martínez and colleagues to incorrect conclusions about the biological role that miR-204 and miR-211 play in melanoma and about the terms of their involvement in the phenomenon of resistance to BRAF inhibitors.

Keywords: BRAF inhibitors; melanoma; miR-204; miR-211; small RNA-seq.