With the continuous development of stem cell research in recent years, it is realized that stem cell aging may be the core issue of organ aging. As an important approach and main content of regenerative medicine, the stem cell research brings great hope to overcome difficult diseases and improve the quality of life for human beings and become the key to solve this issue. Based on this research, the varying characteristics of stem cells in aging could be recognized; the role of stem cells in the organ aging and regeneration will be revealed; the function of stem cells will be controllable and regulatable in tissues and organs; the stem cells from tissues and organs with rapid or slow cell renewal (e.g., liver and neuron) could be continuously observed from the levels of cellular molecules and dynamic complex. With the assistance of systematical research approaches, the function and mechanism studies can be conducted via multi-perspectives and levels during the different stages of organ aging and regeneration. All of the abovementioned requires great efforts to thoroughly understand the basic rule and the way of stem cell regulation in organ aging and regeneration. Final to the end, the dream of antiaging, efficient repair, and organ remodeling could be realized and also can meet the major needs of population health and disease treatment in our country, meaningfully to contribute benefits for the health of human beings.
Keywords: Adult stem cells; Organ aging; Regeneration; Senescence.