Biology and Systemic Treatment of Advanced Gastroenteropancreatic Neuroendocrine Tumors

Am Soc Clin Oncol Educ Book. 2018 May 23:38:292-299. doi: 10.1200/EDBK_200893.

Abstract

In recent years, there have been important scientific advances in the biologic characterization of neuroendocrine neoplasms and in their treatment. This review will describe these scientific advances, the evolving systemic treatment approaches, and important topics to be addressed in future research.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use
  • Biomarkers, Tumor
  • Chromatin Assembly and Disassembly
  • Clinical Trials, Phase III as Topic
  • Combined Modality Therapy / adverse effects
  • Combined Modality Therapy / methods
  • Humans
  • Intestinal Neoplasms / etiology*
  • Intestinal Neoplasms / metabolism
  • Intestinal Neoplasms / pathology
  • Intestinal Neoplasms / therapy*
  • Molecular Targeted Therapy
  • Mutation
  • Neoplasm Metastasis
  • Neoplasm Staging
  • Neuroendocrine Tumors / etiology*
  • Neuroendocrine Tumors / metabolism
  • Neuroendocrine Tumors / pathology
  • Neuroendocrine Tumors / therapy*
  • Pancreatic Neoplasms / etiology*
  • Pancreatic Neoplasms / metabolism
  • Pancreatic Neoplasms / pathology
  • Pancreatic Neoplasms / therapy*
  • Stomach Neoplasms / etiology*
  • Stomach Neoplasms / metabolism
  • Stomach Neoplasms / pathology
  • Stomach Neoplasms / therapy*

Substances

  • Antineoplastic Agents
  • Biomarkers, Tumor

Supplementary concepts

  • Gastro-enteropancreatic neuroendocrine tumor