Association between stroke-like episodes and neuronal hyperexcitability in MELAS with m.3243A>G: A case report

Shota Sakai; Masato Osaki; Masaoki Hidaka; Shunsuke Kimura; Yuichiro Ohya; Tetsuro Ago; Takanari Kitazono; Shuji Arakawa

doi:10.1016/j.ensci.2018.08.003

Association between stroke-like episodes and neuronal hyperexcitability in MELAS with m.3243A>G: A case report

eNeurologicalSci. 2018 Aug 22:12:39-41. doi: 10.1016/j.ensci.2018.08.003. eCollection 2018 Sep.

Authors

Shota Sakai¹, Masato Osaki¹, Masaoki Hidaka¹, Shunsuke Kimura¹, Yuichiro Ohya¹, Tetsuro Ago², Takanari Kitazono², Shuji Arakawa¹

Affiliations

¹ Department of Cerebrovascular Medicine, Steel Memorial Yawata Hospital, 1-1-1 Harunomachi, Yahatahigashi-ku, Kitakyushu, Fukuoka 805-0050, Japan.
² Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, Japan.

Abstract

•The pathophysiology of the stroke-like episodes of MELAS has not completely been elucidated.•Here we report a case of stroke-like episodes, successfully treated with levetiracetam.•Neuronal hyperexcitability can be the underlying mechanism of stroke-like episodes in MELAS.

Keywords: Hyperexcitability; Levetiracetam; MELAS; Stroke-like episodes.