Analysis of the complete genome of hepatitis B virus subgenotype C2 isolate NHB17965 from a HBV infected patient

Modhusudon Shaha; Palash Kumar Sarker; Md Saddam Hossain; Keshob Chandra Das; Munira Jahan; Shuvra Kanti Dey; Shahina Tabassum; Abu Hashem; Md Salimullah

doi:10.12688/f1000research.15090.3

Analysis of the complete genome of hepatitis B virus subgenotype C2 isolate NHB17965 from a HBV infected patient

F1000Res. 2018 Jul 9:7:1023. doi: 10.12688/f1000research.15090.3. eCollection 2018.

Authors

Modhusudon Shaha¹, Palash Kumar Sarker¹, Md Saddam Hossain¹, Keshob Chandra Das², Munira Jahan³, Shuvra Kanti Dey⁴, Shahina Tabassum³, Abu Hashem¹, Md Salimullah²

Affiliations

¹ Microbial Biotechnology Division, National Institute of Biotechnology, Dhaka, 1349, Bangladesh.
² Molecular Biotechnology Division, National Institute of Biotechnology, Dhaka, 1349, Bangladesh.
³ Department of Virology, Bangabandhu Sheikh Mujib Medical University, Dhaka, 1000, Bangladesh.
⁴ Department of Microbiology, Jahangirnagar University, Dhaka, 1342, Bangladesh.

Abstract

The burden of chronic hepatitis B virus (HBV) infections is increasingly detected nowadays. Herein, we report a complete genome of HBV subgenotype C2 (HBV/C2) from a HBV infected patient. Complete genome analysis revealed that the isolated strain was a non-recombinant wild type and had several regular substitutions in the reverse transcriptase domain and small surface proteins of HBV. This study may help clinicians and scientists gain in-depth knowledge on the current substitutions of HBV/C2 genome and to identify potential therapies against HBV infections.

Keywords: Bangladesh; Chronic; HBV/C2; Non-recombinant.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

DNA, Viral*
Genome, Viral*
Hepatitis B virus / genetics*
Hepatitis B, Chronic / genetics*
Humans
Male
Middle Aged

Substances

DNA, Viral

Grants and funding

The study was supported by the National Institute of Biotechnology, Ministry of Science and Technology, Bangladesh.