Total Synthesis of the Highly N-Methylated Peptides Carmabin A and Dragomabin

Mar Drugs. 2018 Sep 17;16(9):338. doi: 10.3390/md16090338.

Abstract

The first total synthesis of carmabin A and dragomabin was achieved at 52.3 mg and 43.8 mg scale, respectively. The synthesis led to determination of the configuration of carmabin A and reassignment of the configuration of dragomabin at the stereogenic centre on the alkyne-bearing fragment.

Keywords: carmabin A; dragomabin; stereochemical determination/revision; total synthesis.

MeSH terms

  • Aquatic Organisms / metabolism*
  • Cyanobacteria / metabolism*
  • Drug Discovery / methods
  • Methylation
  • Molecular Structure
  • Oligopeptides / chemical synthesis*
  • Stereoisomerism

Substances

  • Oligopeptides
  • carmabin A
  • dragomabin