Specific Features of Depolarization of the Left and Right Atria in Rats with Alcoholic Cardiomyopathy

I M Roshchevskaya; S L Smirnova; I B Tsorin; V N Stolyaruk; A V Nadorova; M B Vititnova; L G Kolik; S A Kryzhanovskii

doi:10.1007/s10517-018-4226-3

Specific Features of Depolarization of the Left and Right Atria in Rats with Alcoholic Cardiomyopathy

Bull Exp Biol Med. 2018 Sep;165(5):617-620. doi: 10.1007/s10517-018-4226-3. Epub 2018 Sep 17.

Authors

I M Roshchevskaya¹, S L Smirnova¹, I B Tsorin², V N Stolyaruk², A V Nadorova², M B Vititnova², L G Kolik², S A Kryzhanovskii³

Affiliations

¹ Department of Comparative Cardiology, Komi Research Center, Ural Division of the Russian Academy of Sciences, Syktyvkar, Komi Republic, Russia.
² V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
³ V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia. SAK-538@yandex.ru.

PMID: 30225698
DOI: 10.1007/s10517-018-4226-3

Abstract

Using a translation model of alcoholic cardiomyopathy in rats we showed the presence of an additional abnormal excitation focus in the area of the pulmonary vein lacunae in the left atrium and enhanced heterogeneity of the atrium depolarization pattern. These changes can determine electric instability of the myocardium and induce malignant heart rhythm disturbances including, sudden cardiac death.

Keywords: alcoholic cardiomyopathy; atria; depolarization; rats.

MeSH terms

Action Potentials / drug effects*
Animals
Animals, Outbred Strains
Arrhythmias, Cardiac / physiopathology*
Cardiomyopathy, Alcoholic / physiopathology*
Disease Models, Animal
Electrocardiography
Ethanol / toxicity*
Heart Atria / drug effects*
Heart Atria / physiopathology
Heart Rate / drug effects*
Heart Ventricles / drug effects*
Heart Ventricles / physiopathology
Humans
Male
Myocardial Contraction / drug effects
Myocardium / pathology
Pulmonary Veins / drug effects
Pulmonary Veins / physiopathology
Rats

Substances

Ethanol