Abstract
Dimericursones A and B (1 and 2), two unprecedented hexacyclic dimeric diterpenoids, were obtained from the root barks of Jatropha curcas. Their structures were elucidated by extensive spectroscopic analysis, electronic circular dichroism calculations, and single-crystal X-ray diffraction. Dimericursone B (2) showed significant inhibition on nitric oxide production of lipopolysaccharide-induced RAW264.7 macrophages with IC50 values of 5.65 μM.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anti-Inflammatory Agents / chemistry*
-
Anti-Inflammatory Agents / isolation & purification
-
Anti-Inflammatory Agents / pharmacology
-
Dimerization*
-
Diterpenes / chemistry*
-
Diterpenes / isolation & purification
-
Diterpenes / pharmacology
-
Jatropha / chemistry*
-
Mice
-
Models, Molecular
-
Molecular Conformation
-
Plant Roots / chemistry*
-
RAW 264.7 Cells
Substances
-
Anti-Inflammatory Agents
-
Diterpenes