Ocular cicatricial pemphigoid

Curr Opin Ophthalmol. 2018 Nov;29(6):543-551. doi: 10.1097/ICU.0000000000000517.

Abstract

Purpose of review: This review offers recommendations for monitoring disease status in ocular cicatricial pemphigoid as well therapeutic options including local and systemic therapies.

Recent findings: A negative biopsy on direct immunofluorescence does not preclude a diagnosis of OCP. If a patient's cicatrization is active and/or progressive, systemic immunosuppression should be commenced.

Summary: OCP is a chronic systemic autoimmune disease that requires systemic immunosuppression.

Publication types

  • Review

MeSH terms

  • Autoimmune Diseases / diagnosis*
  • Autoimmune Diseases / drug therapy
  • Biopsy
  • Complement C3 / immunology
  • Conjunctival Diseases / diagnosis*
  • Conjunctival Diseases / drug therapy
  • Epithelial Cells / immunology
  • Epithelial Cells / pathology
  • Humans
  • Immunoglobulin A / immunology
  • Immunosuppressive Agents / therapeutic use
  • Pemphigoid, Benign Mucous Membrane / diagnosis*
  • Pemphigoid, Benign Mucous Membrane / drug therapy

Substances

  • Complement C3
  • Immunoglobulin A
  • Immunosuppressive Agents