Abstract
Amphiphilic polysaccharide self-assembled (SA) nanogels are promising protein carriers owing to their chaperone-like activity that allows them to nanoencapsulate proteins within their polymer networks. The chaperoning function is an important concept that has led to breakthroughs in the development of effective protein drug delivery systems by stabilizing formulations and controlling the quality of unstable proteins. Recently, nanogel-tectonic materials that integrate SA nanogels as building blocks have been designed as new hydrogel biomaterials. This article describes recent progress and applications of SA nanogel tectonic materials as protein delivery systems for tissue engineering.
Keywords:
chaperone-like activity; nanogel tectonics; nanogel-tectonic materials; nanogels; protein delivery; tissue engineering.
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antigens, Neoplasm / chemistry
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Antigens, Neoplasm / immunology
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Antigens, Neoplasm / metabolism
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Bone Diseases / therapy
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Bone Diseases / veterinary
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Bone Morphogenetic Protein 2 / chemistry
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Bone Morphogenetic Protein 2 / metabolism
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Bone Regeneration
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Drug Carriers / chemistry
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Fibroblast Growth Factors / chemistry
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Fibroblast Growth Factors / metabolism
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Humans
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Membrane Proteins / chemistry
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Membrane Proteins / immunology
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Membrane Proteins / metabolism
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Mice
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Molecular Chaperones / chemistry
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Molecular Chaperones / metabolism
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Nanogels
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Polyethylene Glycols / chemistry*
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Polyethylene Glycols / therapeutic use
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Polyethyleneimine / chemistry*
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Polyethyleneimine / therapeutic use
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Polysaccharides / chemistry
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Tissue Engineering*
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beta-Cyclodextrins / chemistry
Substances
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Antigens, Neoplasm
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Bone Morphogenetic Protein 2
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CTAG1B protein, human
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Drug Carriers
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Membrane Proteins
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Molecular Chaperones
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Nanogels
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Polysaccharides
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beta-Cyclodextrins
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fibroblast growth factor 18
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polyethylene glycol polyethyleneimine nanogel
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Polyethylene Glycols
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Fibroblast Growth Factors
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Polyethyleneimine
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betadex