Carbapenemase-producing Enterobacteriaceae among pregnant women and newborns in Algeria: Prevalence, molecular characterization, maternal-neonatal transmission, and risk factors for carriage

Am J Infect Control. 2019 Jan;47(1):105-108. doi: 10.1016/j.ajic.2018.07.009. Epub 2018 Sep 14.

Abstract

The diffusion of carbapenemase-producing Enterobacteriaceae (CPE) represents a worldwide public health problem. This study revealed that the prevalence of OXA-48-producing enterobacteria was 4.6% (19/414) and 1.6% (7/422) in mothers and newborns, respectively, from 2 maternity units in Algeria. Previous hospital admission was an independent factor associated with an increased risk of CPE carriage in the mothers (P = .021). The low birth weight was significantly associated with this carriage in the newborns (P = .008). The screening of these bacteria is essential to prevent the dissemination of CPE.

Keywords: Algeria; Enterobacteriaceae; Mother-newborn pairs; OXA-48; Outbreak; Transmission.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Algeria / epidemiology
  • Carbapenem-Resistant Enterobacteriaceae / classification
  • Carbapenem-Resistant Enterobacteriaceae / genetics
  • Carbapenem-Resistant Enterobacteriaceae / isolation & purification*
  • Carrier State / epidemiology*
  • Carrier State / microbiology
  • Enterobacteriaceae Infections / epidemiology*
  • Enterobacteriaceae Infections / microbiology
  • Enterobacteriaceae Infections / transmission
  • Female
  • Genotype
  • Humans
  • Infant, Newborn
  • Infectious Disease Transmission, Vertical / statistics & numerical data*
  • Male
  • Molecular Typing
  • Pregnancy
  • Pregnancy Complications, Infectious / epidemiology*
  • Pregnancy Complications, Infectious / microbiology
  • Prevalence
  • Risk Factors
  • beta-Lactamases / genetics

Substances

  • beta-Lactamases
  • oxacillinase