Clinical infrared microscopic imaging: An overview

Abstract

New developments in Mid-infrared microscopic imaging instrumentation and data analysis have turned this method into a conventional technique. This imaging method offers a global analysis of samples, with a resolution close to the cellular level enabling the acquisition of local molecular expression profiles. It is possible to get chemo-morphological information about the tissue status, which represents an essential benefit for future analytical interpretation of pathological changes of tissue. In this review, we give an overview of Mid-infrared microscopic imaging and its applications in clinical research.

Keywords: Chemical as well as physical sample properties; Histopathology; Mid-infrared microscopic imaging; Molecular fingerprint; Statistical classification; Three-dimensional image data cube.