Synthesis and evaluation of antibacterial and antibiofilm activities of pyridin-2-yl hexanoate

Bochra Kouidhi; Mohamed Hagar; Nagi R E Radwan; Kamel Chaieb

doi:10.1016/j.micpath.2018.09.022

Synthesis and evaluation of antibacterial and antibiofilm activities of pyridin-2-yl hexanoate

Microb Pathog. 2018 Dec:125:205-209. doi: 10.1016/j.micpath.2018.09.022. Epub 2018 Sep 13.

Authors

Bochra Kouidhi¹, Mohamed Hagar², Nagi R E Radwan³, Kamel Chaieb⁴

Affiliations

¹ Medical Laboratory Department, College of Applied Medical Sciences, Yanbu el Baher Taibah University, Saudi Arabia. Electronic address: bochrak@yahoo.fr.
² College of Sciences, Chemistry Department, Yanbu el Baher, Taibah University, Saudi Arabia; Faculty of Science, Chemistry Department, Alexandria University, Alexandria, Egypt.
³ College of Sciences, Chemistry Department, Yanbu el Baher, Taibah University, Saudi Arabia; Faculty of Science, Chemistry Department, Suez University, Suez, Egypt.
⁴ Laboratory of Analysis, Treatment and Valorization of Pollutants of the Environment and Products, Faculty of Pharmacy, Monastir University, Tunisia.

PMID: 30219392
DOI: 10.1016/j.micpath.2018.09.022

Abstract

Synthesized Pyridin-2-yl hexanoate was screened for its antibacterial and antibiofilm activities using the broth microdilution method and XTT assay respectively. The obtained results revealed that synthesized molecule inhibited the growth of pathogenic bacteria (MICs value ranged from 80 to 640 μg ml^-1). Moreover, it induced a strong antibiofilm effect against Gram positive cocci (BIC₅₀ was 366, 378 and 412 μg ml^-1 for Streptococcus mutans ATCC 25175, Streptococcus salivarius ATCC 13419 and Streptococcus oralis ATCC 6249 respectively). Basis on these results, pyridin-2-yl hexanoate may be considered as effective compound with antibacterial and antibiofilm activities.

Keywords: Antibacterial; Antibiofilm; Pyridin-2-yl hexanoate; XTT assay.

MeSH terms

Anti-Bacterial Agents / chemical synthesis
Anti-Bacterial Agents / pharmacology*
Biofilms / drug effects*
Biofilms / growth & development
Caproates / chemical synthesis
Caproates / pharmacology*
Escherichia coli / drug effects*
Escherichia coli / growth & development
Formazans / analysis
Gram-Positive Bacteria / drug effects*
Gram-Positive Bacteria / growth & development
Microbial Sensitivity Tests
Microbial Viability / drug effects
Pyridines / chemical synthesis
Pyridines / pharmacology*
Staining and Labeling

Substances

Anti-Bacterial Agents
Caproates
Formazans
Pyridines
1,5-bis(2-methoxy-4-nitro-5-sulfophenyl)-3-((phenylamino)carbonyl)formazan