Abstract
In this review we present current evidence on the possibility of umbilical cord tissue cryopreservation for subsequent clinical use. Protocols for obtaining umbilical cord-derived vessels, Wharton's jelly-based grafts, multipotent stromal cells, and other biomedical products from cryopreserved umbilical cords are highlighted, and their prospective clinical applications are discussed. Examination of recent literature indicates we should expect high demand for cryopreservation of umbilical cord tissues in the near future.
Keywords:
Cryoprotectants; Graft; Mesenchymal stem cells; Tissue cryopreservation; Umbilical cord; Vessels.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Biological Specimen Banks
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Blood Vessel Prosthesis
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Cell Differentiation / drug effects
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Cell Proliferation / drug effects
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Cryopreservation / methods*
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Cryoprotective Agents / pharmacology*
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Dimethyl Sulfoxide / pharmacology
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Fetal Blood / cytology
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Fetal Blood / drug effects*
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Fetal Blood / physiology
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Glycerol / pharmacology
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Humans
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Mesenchymal Stem Cells / cytology
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Mesenchymal Stem Cells / drug effects*
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Mesenchymal Stem Cells / physiology
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Umbilical Cord / cytology
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Umbilical Cord / drug effects*
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Umbilical Cord / physiology
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Wharton Jelly / cytology
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Wharton Jelly / drug effects
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Wharton Jelly / physiology
Substances
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Cryoprotective Agents
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Glycerol
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Dimethyl Sulfoxide