Antitumor potential of Pllans-II, an acidic Asp49-PLA2 from Porthidium lansbergii lansbergii snake venom on human cervical carcinoma HeLa cells

Int J Biol Macromol. 2019 Feb 1:122:1053-1061. doi: 10.1016/j.ijbiomac.2018.09.053. Epub 2018 Sep 12.
No abstract available

Keywords: Antitumor activity; Phospholipase A(2); Porthidium lansbergii lansbergii.

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / therapeutic use
  • Apoptosis / drug effects
  • Cell Movement / drug effects
  • Crotalid Venoms / enzymology*
  • Female
  • G1 Phase Cell Cycle Checkpoints / drug effects
  • HeLa Cells
  • Humans
  • Integrins / metabolism
  • MCF-7 Cells
  • Neovascularization, Pathologic / drug therapy
  • Phospholipases A2 / pharmacology*
  • Phospholipases A2 / therapeutic use
  • Uterine Cervical Neoplasms / pathology*

Substances

  • Antineoplastic Agents
  • Crotalid Venoms
  • Integrins
  • Phospholipases A2