FGF23 beyond Phosphotropic Hormone

Trends Endocrinol Metab. 2018 Nov;29(11):755-767. doi: 10.1016/j.tem.2018.08.006. Epub 2018 Sep 11.

Abstract

Fibroblast growth factor (FGF) 23 is a bone-derived phosphotropic hormone that regulates phosphate and vitamin D metabolism. FGF23 mainly affects kidney function via the FGF receptor (FGFR)/α-Klotho complex. The physiological roles of FGF23 and α-Klotho in the regulation of mineral homeostasis have been well established. In addition, recent studies have reported that FGF23 has various effects on many other tissues, sometimes in an α-Klotho-independent manner, especially under pathological conditions. However, how FGF23 works in these tissues without α-Klotho is not entirely clear. Here we review the recent reports concerning the actions of FGF23 on various tissues and discuss the remaining questions about FGF23.

Keywords: chronic kidney disease; fibroblast growth factor 23; fibroblast growth factor receptor; phosphate; α-Klotho.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Fibroblast Growth Factor-23
  • Fibroblast Growth Factors / metabolism*
  • Glucuronidase / metabolism*
  • Hormones / metabolism*
  • Humans
  • Klotho Proteins
  • Phosphates / metabolism*
  • Receptors, Fibroblast Growth Factor / metabolism*
  • Renal Insufficiency, Chronic / metabolism*
  • Vitamin D / metabolism*

Substances

  • FGF23 protein, human
  • Hormones
  • Phosphates
  • Receptors, Fibroblast Growth Factor
  • Vitamin D
  • Fibroblast Growth Factors
  • Fibroblast Growth Factor-23
  • Glucuronidase
  • Klotho Proteins