Role of non-coding RNAs in cardiotoxicity of chemotherapy

Lina Song; Guanglei Qiao; Yingjie Xu; Lijun Ma; Weihua Jiang

doi:10.1016/j.suronc.2018.06.003

Role of non-coding RNAs in cardiotoxicity of chemotherapy

Surg Oncol. 2018 Sep;27(3):526-538. doi: 10.1016/j.suronc.2018.06.003. Epub 2018 Jun 19.

Authors

Lina Song¹, Guanglei Qiao¹, Yingjie Xu², Lijun Ma³, Weihua Jiang⁴

Affiliations

¹ Department of Oncology, Shanghai Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
² Department of Cardiology, Shanghai Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
³ Department of Oncology, Shanghai Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. Electronic address: MLJ1971@shtrhospital.com.
⁴ Department of Oncology, Shanghai Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. Electronic address: whjiang78@hotmail.com.

PMID: 30217315
DOI: 10.1016/j.suronc.2018.06.003

Abstract

The long-time paradoxical situation of non-coding RNAs (ncRNAs) has been terminated for they emerge as executive at full spectrum of gene expression and translation. More recently, it has been demonstrated that some ncRNAs apparently are associated with chemotherapy, causing cardiotoxicity, which taint long-term recovery of patients in growing body of evidence. The current review focused on up-to-date knowledge on regulation change and molecular signaling of ncRNAs, at mean time evaluate their potentials as diagnostic biomarkers or therapeutic targets to monitor and protect cardio function.

Keywords: Cardiotoxicity; Chemotherapy; Non-coding RNA.

Publication types

Review

MeSH terms

Animals
Antineoplastic Agents / adverse effects*
Cardiotoxicity / genetics*
Gene Expression Regulation, Neoplastic*
Humans
Neoplasms / drug therapy*
RNA, Untranslated / genetics*

Substances

Antineoplastic Agents
RNA, Untranslated