Fluorescent-guided surgery for sentinel lymph node detection in gastric cancer and carcinoembryonic antigen targeted fluorescent-guided surgery in colorectal and pancreatic cancer

J Surg Oncol. 2018 Aug;118(2):315-323. doi: 10.1002/jso.25139. Epub 2018 Sep 14.

Abstract

Sentinel lymph node procedures for gastric cancer resections using indocyanine green (ICG) linked to Nanocoll outperformed normal ICG but did not provide information on possible lymph node metastasis. Carcinoembryonic antigen targeted fluorescent imaging using SGM-101 was successful in both pancreatic and colorectal cancer. A large phase III multicentre trial will soon be initiated in colorectal cancer patients.

Keywords: lymphatic metastasis; molecular imaging; pancreatic neoplasm; rectal neoplasm.

Publication types

  • Review

MeSH terms

  • Carcinoembryonic Antigen / metabolism*
  • Colorectal Neoplasms / diagnostic imaging
  • Colorectal Neoplasms / metabolism
  • Colorectal Neoplasms / pathology
  • Colorectal Neoplasms / surgery
  • Digestive System Neoplasms / diagnostic imaging*
  • Digestive System Neoplasms / metabolism
  • Digestive System Neoplasms / pathology
  • Digestive System Neoplasms / surgery*
  • Humans
  • Lymphatic Metastasis
  • Optical Imaging / methods
  • Pancreatic Neoplasms / diagnostic imaging
  • Pancreatic Neoplasms / metabolism
  • Pancreatic Neoplasms / pathology
  • Pancreatic Neoplasms / surgery
  • Sentinel Lymph Node / diagnostic imaging*
  • Sentinel Lymph Node / metabolism
  • Sentinel Lymph Node / pathology
  • Sentinel Lymph Node / surgery
  • Stomach Neoplasms / diagnostic imaging
  • Stomach Neoplasms / metabolism
  • Stomach Neoplasms / pathology
  • Stomach Neoplasms / surgery
  • Surgery, Computer-Assisted / methods*

Substances

  • Carcinoembryonic Antigen