Synthesis of Optically Active α-Trifluoromethylamines by Rearrangement of β-Amino-α-trifluoromethyl Alcohols

Zeina Neouchy; Domingo Gomez Pardo; Janine Cossy

doi:10.1021/acs.orglett.8b02353

Synthesis of Optically Active α-Trifluoromethylamines by Rearrangement of β-Amino-α-trifluoromethyl Alcohols

Org Lett. 2018 Oct 5;20(19):6017-6021. doi: 10.1021/acs.orglett.8b02353. Epub 2018 Sep 14.

Authors

Zeina Neouchy¹, Domingo Gomez Pardo¹, Janine Cossy¹

Affiliation

¹ Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI) , ESPCI Paris/CNRS/PSL University , 10 rue Vauquelin , 75231 Cedex 05 Paris , France.

PMID: 30216084
DOI: 10.1021/acs.orglett.8b02353

Abstract

The synthesis of various optically active α-trifluoromethylamines has been realized from β-amino-α-trifluoromethyl alcohols via an aziridinium ion intermediate under kinetic conditions.