Circular RNA hsa_circ_0000993 inhibits metastasis of gastric cancer cells

Epigenomics. 2018 Oct;10(10):1301-1313. doi: 10.2217/epi-2017-0173. Epub 2018 Sep 14.

Abstract

Aim: We aimed to explore the roles of circRNAs in gastric cancer.

Materials & methods: The dysregulated circRNAs and miRNAs were identified using data from Gene Expression Omnibus. The roles of specifically selected circRNAs were explored. Survival analysis was performed using data from the Cancer Genome Atlas.

Results: We identified 68 dysregulated circRNAs and 51 dysregulated miRNAs. We found that hsa_circ_0000993 inhibited migration, invasion and proliferation of gastric cancer cells and could act as a miRNA sponge for miR-214-5p but did not modulate expression of its parental gene, ATL2. Survival analysis showed that gastric cancer patients with lowly expressed miR-214-5p had a significantly better overall survival.

Conclusion: In conclusion, hsa_circ_0000993 may inhibit metastasis of gastric cancer through sequestering miR-214-5p.

Keywords: ATL2; circular RNA; invasion; metastasis; microRNA; migration; prognosis; proliferation; stomach carcinoma; survival.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Cell Line, Tumor
  • Cell Movement
  • Datasets as Topic
  • Gene Expression Profiling
  • Humans
  • Male
  • MicroRNAs / metabolism
  • Middle Aged
  • Neoplasm Metastasis
  • Oligonucleotide Array Sequence Analysis
  • RNA / metabolism*
  • RNA / physiology
  • RNA, Circular
  • Stomach Neoplasms / genetics*
  • Stomach Neoplasms / metabolism
  • Stomach Neoplasms / mortality
  • Stomach Neoplasms / pathology
  • Survival Analysis

Substances

  • MIRN214 microRNA, human
  • MicroRNAs
  • RNA, Circular
  • RNA