Long-term follow up of pediatric Philadelphia positive acute lymphoblastic leukemia treated with the EsPhALL2004 study: high white blood cell count at diagnosis is the strongest prognostic factor

Andrea Biondi; Gunnar Cario; Paola De Lorenzo; Anders Castor; Valentino Conter; Veronica Leoni; Virginie Gandemer; Rob Pieters; Jan Stary; Gabriele Escherich; Myriam Campbell; Andishe Attarbaschi; Chi-Kong Li; Ajay Vora; Jutta Bradtke; Vaskar Saha; Maria Grazia Valsecchi; Martin Schrappe

doi:10.3324/haematol.2018.199422

Long-term follow up of pediatric Philadelphia positive acute lymphoblastic leukemia treated with the EsPhALL2004 study: high white blood cell count at diagnosis is the strongest prognostic factor

Haematologica. 2019 Jan;104(1):e13-e16. doi: 10.3324/haematol.2018.199422. Epub 2018 Sep 13.

Authors

Andrea Biondi^{1

2}, Gunnar Cario³, Paola De Lorenzo^{4

5}, Anders Castor⁶, Valentino Conter⁴, Veronica Leoni⁴, Virginie Gandemer⁷, Rob Pieters⁸, Jan Stary⁹, Gabriele Escherich¹⁰, Myriam Campbell¹¹, Andishe Attarbaschi¹², Chi-Kong Li¹³, Ajay Vora¹⁴, Jutta Bradtke¹⁵, Vaskar Saha¹⁶, Maria Grazia Valsecchi⁵, Martin Schrappe³

Affiliations

¹ Pediatric Department, University of Milano-Bicocca, Fondazione MBBM/San Gerardo Hospital, Monza, Italy abiondi.unimib@gmail.com.
² Centro Ricerca Tettamanti, Pediatric Department, University of Milano-Bicocca, Fondazione MBBM, Monza, Italy.
³ University Medical Center, Christian-Albrechts-University Kiel, Germany.
⁴ Pediatric Department, University of Milano-Bicocca, Fondazione MBBM/San Gerardo Hospital, Monza, Italy.
⁵ EsPhALL Trial Data Center, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
⁶ Department of Pediatric Oncology, Skane University Hospital, Lund, Sweden.
⁷ CHU Hôpital Sud, Rennes, France.
⁸ Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
⁹ University Hospital Motol, Department of Pediatric Hematology and Oncology, Prague, Czech Republic.
¹⁰ University Medical Center Eppendorf, Clinic of Pediatric Hematology and Oncology, Hamburg, Germany.
¹¹ Chilean National Pediatric Oncology Group, PINDA, Hospital Roberto del Rio, Santiago, Chile.
¹² Department of Pediatric Hematology and Oncology, St. Anna Children's Hospital, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Austria.
¹³ The Chinese University of Hong Kong, China.
¹⁴ Great Ormond Street Hospital for Children, London, UK.
¹⁵ Department of Pediatric Hematology and Oncology, Justus Liebig University, Giessen, Germany.
¹⁶ Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK.

No abstract available

Keywords: Philadelphia chromosome; acute lymphoblastic leukemia (ALL); pre-tyrosine kinase inhibitors (TKIs).

Publication types

Clinical Trial
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Child
Child, Preschool
Disease-Free Survival
Female
Follow-Up Studies
Humans
Imatinib Mesylate / administration & dosage*
Infant
Leukocyte Count
Male
Philadelphia Chromosome*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / mortality*
Survival Rate

Substances

Imatinib Mesylate

Publication types

MeSH terms

Substances

Grants and funding