RETRACTED: miR-217 represses TGF-β1-induced airway smooth muscle cell proliferation and migration through targeting ZEB1

Biomed Pharmacother. 2018 Dec:108:27-35. doi: 10.1016/j.biopha.2018.09.030. Epub 2018 Sep 11.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. The journal was alerted to several suspected image similarities within Figures 2C and 3B, between Figure 3B and 5E, and an image in Figure 3A appears to be present in another publication, as detailed here: https://pubpeer.com/publications/F4E8CA0032EF5375E7867504F3FC4A. These findings were confirmed as part of an internal investigation, and in addition, a portion of Figure 2C, ‘Scramble’ group appears to contain image similarities with Figure 5D ‘miR-217 mimic + ZEB1’ group. The journal requested the authors provide explanations and source data relating to these affected figures, but the Authors did not respond to these concerns. The Editor-in-Chief assessed this case and decided to retract the article.

Keywords: ASMC; Asthma; Proliferation and migration; TGF-β1; ZEB1; miR-217.

Publication types

  • Retracted Publication

MeSH terms

  • Base Sequence
  • Cell Movement* / drug effects
  • Cell Proliferation / drug effects
  • Down-Regulation / genetics
  • Extracellular Matrix / drug effects
  • Extracellular Matrix / metabolism
  • Fibronectins / genetics
  • Fibronectins / metabolism
  • Humans
  • Lung / cytology*
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • Myocytes, Smooth Muscle / cytology*
  • Myocytes, Smooth Muscle / drug effects
  • Myocytes, Smooth Muscle / metabolism*
  • Promoter Regions, Genetic / genetics
  • Protein Binding / drug effects
  • Signal Transduction / drug effects
  • Transforming Growth Factor beta1 / pharmacology*
  • Zinc Finger E-box-Binding Homeobox 1 / genetics
  • Zinc Finger E-box-Binding Homeobox 1 / metabolism*

Substances

  • Fibronectins
  • MIRN217 microRNA, human
  • MicroRNAs
  • Transforming Growth Factor beta1
  • ZEB1 protein, human
  • Zinc Finger E-box-Binding Homeobox 1