NLRP12: The Monarch of the Gut

Hengameh Sadeghi; Suzanne Devkota; Fayyaz S Sutterwala

doi:10.1016/j.chom.2018.08.010

NLRP12: The Monarch of the Gut

Cell Host Microbe. 2018 Sep 12;24(3):326-328. doi: 10.1016/j.chom.2018.08.010.

Authors

Hengameh Sadeghi¹, Suzanne Devkota², Fayyaz S Sutterwala³

Affiliations

¹ Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
² Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
³ Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Electronic address: fayyaz.sutterwala@cshs.org.

PMID: 30212643
DOI: 10.1016/j.chom.2018.08.010

Abstract

Innate pattern recognition receptors have been implicated in the obesity-associated imbalance of gut microbiota. In this issue of Cell Host & Microbe, Truax et al. (2018) report that NLRP12 prevents high-fat-diet-induced obesity by maintaining beneficial short-chain fatty acid-producing microbiota.

Publication types

Comment

MeSH terms

Diet, High-Fat
Gastrointestinal Microbiome*
Homeostasis
Humans
Immunity, Innate
Intracellular Signaling Peptides and Proteins
Obesity / prevention & control

Substances

Intracellular Signaling Peptides and Proteins
NLRP12 protein, human

Grants and funding

R01 AI118719/AI/NIAID NIH HHS/United States