Real-time personalized motion monitoring and analysis are important for human health. Thus, to satisfy the needs in this area and the ever-increasing demand for wearable electronics, we design and develop a wireless piezoelectric device consisting of a piezoelectric pressure sensor based on electrospun PVDF/BaTiO3 nanowire (NW) nanocomposite fibers and a wireless circuit system integrated with a data conversion control module, a signal acquisition and amplification module, and a Bluetooth module. Finally, real-time piezoelectric signals of human motion can be displayed by an App on an Android mobile phone for wireless monitoring and analysis. This wireless piezoelectric device is proven to be sensitive to human motion such as squatting up and down, walking, and running. The results indicate that our wireless piezoelectric device has potential applications in wearable medical electronics, particularly in the fields of rehabilitation and sports medicine.