tert-Butyl nitrite mediated nitrogen transfer reactions: synthesis of benzotriazoles and azides at room temperature

Sadaf Azeez; Priyanka Chaudhary; Popuri Sureshbabu; Shahulhameed Sabiah; Jeyakumar Kandasamy

doi:10.1039/c8ob01950a

tert-Butyl nitrite mediated nitrogen transfer reactions: synthesis of benzotriazoles and azides at room temperature

Org Biomol Chem. 2018 Sep 26;16(37):8280-8285. doi: 10.1039/c8ob01950a.

Authors

Sadaf Azeez¹, Priyanka Chaudhary, Popuri Sureshbabu, Shahulhameed Sabiah, Jeyakumar Kandasamy

Affiliation

¹ Department of chemistry, Indian Institute of Technology (BHU), Varanasi, Uttar Pradesh-221005, India. jeyakumar.chy@iitbhu.ac.in.

PMID: 30209482
DOI: 10.1039/c8ob01950a

Abstract

A conversion of o-phenylenediamines into benzotriazoles was achieved at room temperature using tert-butyl nitrite. The optimized conditions are also well suited for the transformation of sulfonyl and acyl hydrazines into corresponding azides. This protocol does not require any catalyst or acidic medium. The desired products were obtained in excellent yields in a short span of time.

Publication types

Research Support, Non-U.S. Gov't