Abstract
The first total synthesis of chaetoglobin A (1), which features a chiral axis between two identical highly oxygenated bicyclic cores, was successfully completed in 12 steps from 2,6-dimethoxytoluene. Vanadium-catalyzed oxidative phenol coupling, as a key step, enabled generation of the axial chirality.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Catalysis
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Isoquinolines / chemical synthesis*
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Isoquinolines / chemistry
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Molecular Conformation
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Oxidative Coupling
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Phenols / chemistry*
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Vanadium / chemistry*
Substances
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Isoquinolines
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Phenols
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chaetoglobin A
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Vanadium