Candida auris: Epidemiology, risk factors, virulence, resistance, and therapeutic options

Microb Pathog. 2018 Dec:125:116-121. doi: 10.1016/j.micpath.2018.09.014. Epub 2018 Sep 8.

Abstract

Candida auris emerged as a pathogen resistant to multiple antifungal and has been associated with nosocomial outbreaks with high transmission capacity between hospitalized individuals. C. auris was first described in 2009, after being isolated from the external ear canal discharge of a patient in Japan. The difficulty in identification, incorrect use of antifungal drugs, and treatment failure are causes of high mortality. Since then, C. auris has been increasingly reported from East Asia to North America, with substantial fatalities and misidentification. This review aims at describing the epidemiology, virulence, risk factors, resistance, and therapeutic options in C. auris infections.

Keywords: Candida auris; Resistance; Virulence factor.

Publication types

  • Review

MeSH terms

  • Antifungal Agents / pharmacology
  • Antifungal Agents / therapeutic use
  • Asia / epidemiology
  • Candida / drug effects
  • Candida / isolation & purification*
  • Candida / pathogenicity
  • Candidiasis / drug therapy
  • Candidiasis / epidemiology*
  • Candidiasis / microbiology*
  • Candidiasis / pathology
  • Cross Infection / drug therapy
  • Cross Infection / epidemiology*
  • Cross Infection / microbiology*
  • Cross Infection / pathology
  • Drug Resistance, Fungal
  • Humans
  • North America / epidemiology
  • Risk Factors
  • Survival Analysis
  • Virulence

Substances

  • Antifungal Agents