Lower perinatal exposure to Proteobacteria is an independent predictor of early childhood wheezing

Benjamin A Turturice; Diane R Gold; Augusto A Litonjua; Emily Oken; Sheryl Rifas-Shiman; David L Perkins; Patricia W Finn

doi:10.1016/j.jaci.2018.06.051

Lower perinatal exposure to Proteobacteria is an independent predictor of early childhood wheezing

J Allergy Clin Immunol. 2019 Jan;143(1):419-421.e5. doi: 10.1016/j.jaci.2018.06.051. Epub 2018 Sep 8.

Authors

Benjamin A Turturice¹, Diane R Gold², Augusto A Litonjua³, Emily Oken⁴, Sheryl Rifas-Shiman⁴, David L Perkins⁵, Patricia W Finn⁶

Affiliations

¹ Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Ill; Department of Medicine, Division of Pulmonary, Critical Care, Sleep, and Allergy, University of Illinois at Chicago, Chicago, Ill.
² Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Mass.
³ Department of Pediatrics, University of Rochester, Rochester, NY.
⁴ Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Mass.
⁵ Department of Medicine, Division of Nephrology, University of Illinois at Chicago, Chicago, Ill; Department of Bioengineering, University of Illinois at Chicago, Chicago, Ill.
⁶ Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Ill; Department of Medicine, Division of Pulmonary, Critical Care, Sleep, and Allergy, University of Illinois at Chicago, Chicago, Ill. Electronic address: pwfinn@uic.edu.

Abstract

Circulating free Proteobacterial DNA in umbilical cord serum is associated with features of childhood asthma including maternal atopy, early childhood wheezing, and bronchodilator response.

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

Asthma / etiology
Asthma / immunology*
Child
Female
Humans
Male
Pregnancy
Prenatal Exposure Delayed Effects / immunology*
Proteobacteria / immunology*
Respiratory Sounds / immunology*
Superior Sagittal Sinus

Abstract

Publication types

MeSH terms

Grants and funding