Mitochondrial dsRNA: A New DAMP for MDA5

Andreas Linder; Veit Hornung

doi:10.1016/j.devcel.2018.08.019

Mitochondrial dsRNA: A New DAMP for MDA5

Dev Cell. 2018 Sep 10;46(5):530-532. doi: 10.1016/j.devcel.2018.08.019.

Authors

Andreas Linder¹, Veit Hornung²

Affiliations

¹ Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich 81377, Germany; Department of Medicine II, University Hospital, Ludwig-Maximilians-Universität München, Munich 81377, Germany.
² Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich 81377, Germany; Center for Integrated Protein Science Munich, Munich 81377, Germany. Electronic address: hornung@genzentrum.lmu.de.

PMID: 30205036
DOI: 10.1016/j.devcel.2018.08.019

Abstract

The role of mitochondria as a signaling platform downstream of the RNA sensors RIG-I and MDA5 is well defined. Now, a recent study in Nature by Dhir et al. (2018) identifies mitochondrial dsRNA as an immunogenic ligand, adding another intriguing aspect to the role of mitochondria in innate immunity.

Publication types

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MeSH terms

DEAD-box RNA Helicases / genetics*
Immunity, Innate
Interferon-Induced Helicase, IFIH1*
Mitochondria
RNA, Double-Stranded

Substances

RNA, Double-Stranded
DEAD-box RNA Helicases
Interferon-Induced Helicase, IFIH1