Pregnancy and Naltrexone Pharmacotherapy

Obstet Gynecol. 2018 Oct;132(4):923-925. doi: 10.1097/AOG.0000000000002864.

Abstract

A 25-year-old woman, gravida 3 para 2 at 12 weeks of gestation, with two prior cesarean deliveries, presents for prenatal care. She is in treatment for opioid use disorder on extended-release naltrexone injection, with a history of opioid overdose, relapse, and poor treatment adherence on methadone and buprenorphine. She asks, "Is it safe for my baby if I continue on this medication? How will you manage my postoperative pain?"

MeSH terms

  • Adult
  • Delivery, Obstetric / adverse effects
  • Female
  • Humans
  • Naltrexone / administration & dosage*
  • Narcotic Antagonists / administration & dosage*
  • Opioid-Related Disorders / rehabilitation*
  • Pain, Postoperative / drug therapy*
  • Pain, Postoperative / etiology
  • Pregnancy
  • Pregnancy Complications / rehabilitation*

Substances

  • Narcotic Antagonists
  • Naltrexone