Impact of RSV Coinfection on Human Bocavirus in Children with Acute Respiratory Infections

Huiming Sun; Jiyang Sun; Wei Ji; Chuangli Hao; Yongdong Yan; Zhengrong Chen; Yuqing Wang

doi:10.1093/tropej/fmy057

Impact of RSV Coinfection on Human Bocavirus in Children with Acute Respiratory Infections

J Trop Pediatr. 2019 Aug 1;65(4):342-351. doi: 10.1093/tropej/fmy057.

Authors

Huiming Sun¹, Jiyang Sun¹, Wei Ji², Chuangli Hao³, Yongdong Yan⁴, Zhengrong Chen⁴, Yuqing Wang⁴

Affiliations

¹ Attending, Department of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
² Chief Physician, Department of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
³ Director, Department of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
⁴ Vice Director, Department of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.

Abstract

Objective: The objective of this study was to assess epidemiological and clinical features of human bocavirus (HBoV) coinfection with other viruses.

Method: Children coinfected with HBoV between January 2012 and December 2014 were enrolled and retrospectively reviewed.

Result: A total of 984 patients were stratified into five groups: HBoV infection alone (n = 249), respiratory syncytial virus (RSV) infection alone (n = 649), HBoV coinfection with RSV (n = 28), with human rhinovirus (HRV) (n = 39) and with other virus (n = 19). Length of hospitalization was longer in HBoV coinfection with RSV group than HBoV (9.0 days vs. 7.0 days, p = 0.001), RSV (9.0 days vs. 8.0 days, p = 0.016) infection alone group. Pneumonia was more common in the HBoV coinfection with RSV group compared with the HBoV, RSV infection alone group, respectively (75.0% vs. 44.2%, 31.3%, p < 0.001). HBoV DNA copy numbers (383 000 copies/ml) were positively correlated with the length of hospitalization (r = 0.334, p < 0.001).

Conclusion: HBoV coinfection with RSV increases HBoV infection severity.

Keywords: acute respiratory infections; coinfection; disease severity; human bocavirus; respiratory syncytial virus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Child
Child, Preschool
China / epidemiology
Coinfection / epidemiology
Coinfection / virology*
DNA, Viral / genetics
Female
Hospitalization
Human bocavirus / isolation & purification*
Humans
Infant
Male
Nasopharynx / virology*
Parvoviridae Infections / diagnosis*
Parvoviridae Infections / epidemiology
Parvoviridae Infections / virology
Pneumonia / diagnosis*
Pneumonia / epidemiology
Pneumonia / virology
RNA, Viral / genetics
Respiratory Syncytial Virus Infections / diagnosis*
Respiratory Syncytial Virus Infections / epidemiology
Respiratory Syncytial Virus Infections / virology
Respiratory Tract Infections / diagnosis*
Respiratory Tract Infections / epidemiology
Respiratory Tract Infections / virology
Retrospective Studies
Severity of Illness Index

Substances

DNA, Viral
RNA, Viral