Tumor heterogeneity is one of the characteristics of malignant tumors, which can cause differences in tumor growth rate, invasion, migration, drug sensitivity and prognosis. Discoveries and development upon on tumor-driver genes and targeted therapy paved the way on dealing with cancer diagnosis and treatment. However, the existence of tumor heterogeneity makes malignant tumor more hardly to overcome. It is generally present and far more complicated during the process of cancer recurrence, development and evolution. Thus, it has becoming key areas in precision medicine regarding to designing optimal therapeutic approaches targeting the mechanisms and phenotypes of tumor heterogeneity, based on novel detecting techniques and new concepts and theory. This review summarized the current references on tumor heterogeneity, in order to better understand the function and mechanisms, and eventually manage tumor heterogeneity through various methods. .
【中文题目：如何认识和处理肿瘤异质性】 【中文摘要：肿瘤异质性是恶性肿瘤的特征之一，可使肿瘤的生长速度、侵袭与转移、药物敏感性、预后等各方面产生差异。肿瘤驱动基因和靶向药物的发现发展开启了战胜肿瘤的希望之门，然而异质性的存在又让肿瘤治疗陷入了难以攻克的困境。在肿瘤复发、进展演化的过程中肿瘤异质性如影随形，纷繁复杂。凭借不断进步的检测技术认识和理解肿瘤异质性，针对肿瘤异质性的原因和表型，定制治疗方案已成为当今精准医疗领域的重点范畴。本综述对肿瘤异质性进行了分析和探讨，从而更好的帮助我们了解肿瘤异质性，有利于我们通过多种手段对抗肿瘤异质性。】 【中文关键词：肿瘤异质性；精准医疗；驱动基因；新技术】.
Keywords: Driver genes; Heterogeneity; Novel technology; Precise medicine.