Inductive Coupling and Flow for Increased NMR Sensitivity

Anal Chem. 2018 Oct 2;90(19):11169-11173. doi: 10.1021/acs.analchem.8b01775. Epub 2018 Sep 11.

Abstract

A device is proposed to enhance the NMR sensitivity of slowly relaxing nuclei, taking advantage of a controlled solution flow within a microfluidic circuit and microsized NMR detection. Unlike our previous work ( Carret et al. Anal. Chem. 2017 , 89 ( 5 ), 2995 - 3000 ), this setup can be easily installed on any commercial NMR probehead as it uses induction between the commercial antenna and the microcoil. Such a system leads to a significant gain in sensitivity per time unit for slowly relaxing nuclei while preserving the capabilities of the host probehead.

Publication types

  • Research Support, Non-U.S. Gov't