[Hypofractioned radiotherapy in elderly patient with glioblastoma]

Abstract

Glioblastoma is the most frequent primary brain tumor, with more than half of all patients being at least 65 years old. The treatment of the elderly in this pathology represents therefore a considerable challenge for oncologists and radiation therapists. However, in most clinical trials, age is a non-eligible criterial. In the last ten years, geriatric therapeutic trials have been multiplied. The treatment of glioblastoma consists of adjuvant chemoradiotherapy. In elderly patients, the evaluation of performans status and the molecular characteristics of the tumor are important factors in order to propose the appropriate treatment in terms of efficacy and toxicity.

Keywords: Elderly; Glioblastoma; Glioblastome; Hypofractionated radiotherapy; Personnes âgées; Radiothérapie hypofractionée; Temozolomide; Témozolomide.