L-[S-methyl-11C]methionine - An example of radiosynthetic optimization

Verena Pichler; Chrysoula Vraka; Neydher Berroterán-Infante; Andreas Krcal; Harald Eidherr; Tatjana Traub-Weidinger; Marcus Hacker; Markus Mitterhauser; Wolfgang Wadsak

doi:10.1016/j.apradiso.2018.08.021

L-[S-methyl-¹¹C]methionine - An example of radiosynthetic optimization

Appl Radiat Isot. 2018 Nov:141:107-111. doi: 10.1016/j.apradiso.2018.08.021. Epub 2018 Aug 29.

Authors

Verena Pichler¹, Chrysoula Vraka², Neydher Berroterán-Infante², Andreas Krcal², Harald Eidherr², Tatjana Traub-Weidinger², Marcus Hacker², Markus Mitterhauser³, Wolfgang Wadsak⁴

Affiliations

¹ Department of Biomedical Imaging and Image-Guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. Electronic address: verena.pichler@meduniwien.ac.at.
² Department of Biomedical Imaging and Image-Guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
³ Department of Biomedical Imaging and Image-Guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria; Ludwig Boltzmann Institute Applied Diagnostics, Vienna, Austria.
⁴ Department of Biomedical Imaging and Image-Guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria; CBmed GmbH - Center for Biomarker Research in Medicine, Graz, Austria.

PMID: 30196247
DOI: 10.1016/j.apradiso.2018.08.021

Abstract

Radiosynthetic optimization is crucial in routine PET production but is often neglected in literature. Small changes in the radiochemical procedure can increase the yield significantly and reduce time fluctuation within the synthetic procedure enabling better planning and product release on time. Therefore, a highly reproducible production method for L-[S-methyl-¹¹C]methionine is presented, which uses a fully automated GE TRACERlab FX C Pro synthesizer. Evolution of the synthetic procedure lead to a protocol with a nearly doubled absolute yield.

Keywords: Carbon-11; L-[S-methyl-(11)C]methionine; PET-tracer; Radiopharmaceuticals; [(11)C]MeI production.