Lower expression of plasma-derived exosome miR-21 levels in HIV-1 elite controllers with decreasing CD4 T cell count

J Microbiol Immunol Infect. 2019 Aug;52(4):667-671. doi: 10.1016/j.jmii.2018.07.007. Epub 2018 Aug 24.

Abstract

Exosome-derived miR-21 was independently associated with CD4 T cell decline in HIV-1-infected elite controllers (OR 0.369, 95% CI 0.137-0.994, p = 0.049). Also, a negative correlation between miR-21 expression and MCP-1 level was found (r = -0.649, p = 0.020), while no correlation between soluble biomarkers or cellular immune activation was found.

Keywords: Elite controllers; Exosomes; HIV-1; Immune activation; Soluble biomarkers; miRNAs.

MeSH terms

  • Adult
  • Biomarkers / blood
  • CD4 Lymphocyte Count
  • CD4-Positive T-Lymphocytes / immunology*
  • Chemokine CCL2 / blood
  • Cross-Sectional Studies
  • Exosomes*
  • Female
  • HIV Infections / immunology*
  • HIV-1
  • Humans
  • Male
  • MicroRNAs / blood*
  • Middle Aged
  • Plasma / immunology*

Substances

  • Biomarkers
  • CCL2 protein, human
  • Chemokine CCL2
  • MIRN21 microRNA, human
  • MicroRNAs