Abstract
A precisely positioned sulfimide chiral center on-tether of a thio-ether tethered peptide determines the peptide secondary structure by chemoselective oxaziridine modification. This method provides a facile way to tune peptides' secondary structures and biophysical properties.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Chromatography, High Pressure Liquid
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Ethers / chemistry*
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HeLa Cells
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Humans
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Molecular Dynamics Simulation
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Peptides / chemistry*
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Protein Structure, Secondary
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Stereoisomerism
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Sulfhydryl Compounds / chemistry*
Substances
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Ethers
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Peptides
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Sulfhydryl Compounds