Au(III) and Pt(II) Complexes of a Novel and Versatile 1,4-Disubstituted 1,2,3-Triazole-Based Ligand Possessing Diverse Secondary and Tertiary Coordinating Groups

Eolann Kitteringham; Zehao Zhou; Brendan Twamley; Darren M Griffith

doi:10.1021/acs.inorgchem.8b01994

Au(III) and Pt(II) Complexes of a Novel and Versatile 1,4-Disubstituted 1,2,3-Triazole-Based Ligand Possessing Diverse Secondary and Tertiary Coordinating Groups

Inorg Chem. 2018 Oct 1;57(19):12282-12290. doi: 10.1021/acs.inorgchem.8b01994. Epub 2018 Sep 7.

Authors

Eolann Kitteringham¹, Zehao Zhou², Brendan Twamley³, Darren M Griffith¹

Affiliations

¹ Department of Chemistry , RCSI , 123 St. Stephens Green , Dublin 2 , Ireland.
² College of Pharmaceutical Sciences , Soochow University , 199 Ren'ai Rd., Suzhou Industrial Park , Soochow , Jiangsu , China , 215123.
³ School of Chemistry , Trinity College Dublin, University of Dublin , Dublin 2 , Ireland.

PMID: 30192529
DOI: 10.1021/acs.inorgchem.8b01994

Abstract

A novel 1,4-disubstituted 1,2,3-triazole-based ligand, 2-(4-(pyridin-2-yl)-1 H-1,2,3-triazol-1-yl)propane-1,3-diamine (ptpd), which possesses pyridyl and diamino secondary and tertiary coordinating groups was synthesized in excellent yield. The reactivity of 2-(1-phenyl-1 H-1,2,3-triazol-4-yl)pyridine (ptp), di- tert-butyl (2-azidopropane-1,3-diyl)dicarbamate (Boc₂-ptpd), and ptpd·3HCl was investigated with Au(III) and Pt(II) precursors. Analysis including X-ray crystal structures of [Au(III)Cl₃(ptp)] (1), [Au(III)Cl₂(ptpd)][Au(I)Cl₂][OH]{[NaAuCl₄·2H₂O]} n (3), and [Pt(II)Cl₂(ptpdH₂)][PtCl₄] (4) revealed that ptpd (i) serves as a monodentate ligand for Au(III) coordinating to the metal center via the pyridine nitrogen only, (ii) preferentially coordinates Au(III) via the bidentate diamino group over the monodentate pyridine group, (iii) can coordinate Pt(II) in a bidentate fashion via the pyridyl nitrogen and the triazole N-3, and (iv) can bridge two Pt(II) centers through bidentate chelation at the diamino group and bidentate chelation via the pyridyl nitrogen and the triazole N-3. ptpd represents a versatile ligand template for the development of mixed metal complexes.