Development of a novel target module redirecting UniCAR T cells to Sialyl Tn-expressing tumor cells

L R Loureiro; A Feldmann; R Bergmann; S Koristka; N Berndt; C Arndt; J Pietzsch; C Novo; P Videira; M Bachmann

doi:10.1038/s41408-018-0113-4

Development of a novel target module redirecting UniCAR T cells to Sialyl Tn-expressing tumor cells

Blood Cancer J. 2018 Aug 22;8(9):81. doi: 10.1038/s41408-018-0113-4.

Authors

L R Loureiro^{1

2

3}, A Feldmann², R Bergmann², S Koristka², N Berndt^{2

4}, C Arndt², J Pietzsch^{2

5}, C Novo^{1

6

7}, P Videira^{1

6

7}, M Bachmann^{8

9

10

11}

Affiliations

¹ UCIBIO, Departamento Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Lisboa, Portugal.
² Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Institute of Radiopharmaceutical Cancer Research, Dresden, Germany.
³ UniversityCancerCenter (UCC) Dresden, Tumor Immunology, 'Carl Gustav Carus' Technische Universität Dresden, Dresden, Germany.
⁴ German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), partner site Dresden, Heidelberg, Germany.
⁵ Faculty of Chemistry and Food Chemistry, School of Science, Technische Universität Dresden, Dresden, Germany.
⁶ UEIPM, Instituto de Higiene e Medicina Tropical, Universidade NOVA de Lisboa, Lisboa, Portugal.
⁷ CDG & Allies, Professional and Patient Association International Network (PPAIN), Caparica, Portugal.
⁸ Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Institute of Radiopharmaceutical Cancer Research, Dresden, Germany. M.Bachmann@hzdr.de.
⁹ UniversityCancerCenter (UCC) Dresden, Tumor Immunology, 'Carl Gustav Carus' Technische Universität Dresden, Dresden, Germany. M.Bachmann@hzdr.de.
¹⁰ German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), partner site Dresden, Heidelberg, Germany. M.Bachmann@hzdr.de.
¹¹ National Center of Tumor Diseases (NCT), partner site Dresden, Dresden, Germany. M.Bachmann@hzdr.de.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antigens, Tumor-Associated, Carbohydrate / immunology*
Biomarkers, Tumor
Cytotoxicity, Immunologic
Disease Models, Animal
Humans
Immunotherapy, Adoptive* / methods
Mice
Neoplasms / immunology
Neoplasms / metabolism
Neoplasms / pathology
Neoplasms / therapy
Receptors, Antigen, T-Cell / genetics
Receptors, Antigen, T-Cell / metabolism*
Receptors, Chimeric Antigen / genetics
Receptors, Chimeric Antigen / metabolism*
T-Lymphocytes / immunology*
T-Lymphocytes / metabolism
Xenograft Model Antitumor Assays

Substances

Antigens, Tumor-Associated, Carbohydrate
Biomarkers, Tumor
Receptors, Antigen, T-Cell
Receptors, Chimeric Antigen
sialosyl-Tn antigen