Operant over-responding is more sensitive than reversal learning for revealing behavioral changes after withdrawal from alcohol consumption

Abstract

In humans, prior alcohol use is linked with impulsivity and impaired decision-making, but the nature of this relationship is unclear. In a previous study in rats, we found that prior alcohol access led to over-responding in go/no-go discrimination training, but had no effect on discrimination learning. It was unclear whether this over-responding effect would occur in a reversal learning task, or whether prior alcohol would impair reversal learning in our task. In the present experiments, we determined whether six weeks of chronic intermittent alcohol access would induce over-responding or impair reversal learning in our task. Our task allowed for multiple responses/trial with limited reinforcement, so over-responding could be assessed. In Exp. 1, we gave three days of discrimination training prior to access to 20% alcohol or water, then reversed task contingencies starting 4 days after the end of alcohol access. In Exp. 2, we gave either three or six days of discrimination training prior to the same alcohol access and reversal learning procedures to determine if the original training length would affect alcohol's behavioral effects. We found no reversal learning deficits in either experiment. Across both experiments, we found that the Alcohol group exhibited over-responding to the active lever, but this effect was smaller than in our previous discrimination experiments. Our data suggest that there are behavioral changes after voluntary alcohol access that can be missed by some discrimination/reversal learning assessments, and our over-responding task can detect these transient changes. However, over-responding is more pronounced in discrimination than reversal learning.

Keywords: Alcohol; Response inhibition; Reversal learning.