[BLOCKING SENSORIMOTOR DISORDERS IN STRIATIC DOPAMINERGIC DEFICIENT MICE BY THE EXTRACTS OF "REMEDY BEETLE" ALPHITOBIUS DIAPERINUS]

Ross Fiziol Zh Im I M Sechenova. 2016 Apr;102(4):436-41.
[Article in Russian]

Abstract

Five groups of C57Bl/6JSto mice (groups 1-5) were tested on a vertical pole 2 weeks since subcutaneous administration of proneurotoxin MPTP (40 mg per kg b. w.) to groups 2-5. Group 1 served as control. It is known that this MPTP dosage forms within 2 weeks sensorimotor disturbances similar to the initial stage of Parkinson's disease. One week before MPTP injection and during all the period after it (2 weeks) animals of groups 3-5 got one of the three extracts of biomass homogenate of the «remedy beetle» Alphitobius diaperinus as an additive to their food (8 g per 1 kg of food). The extracts were as follows: water (N 1), water-methanol (N 2) and water-methanol one after solid-phase extraction (N 3). All extracts were immobilized on a phytocarrier. Animals of groups 1 & 2 used ordinary food. Sensorimotor disturbances which could be clearly seen in the 2nd group of mice (MPTP) were absent in group 1 (control) as well as groups 3-5 which received an «antidote» with their food as one of the extracts of homogenate of the beetle biomass. The extract N 3 demonstrated maximal efficiency of all.

MeSH terms

  • Animals
  • Biological Products / pharmacology*
  • Biological Products / therapeutic use
  • Coleoptera / chemistry*
  • Corpus Striatum / drug effects
  • Dopaminergic Neurons / drug effects
  • MPTP Poisoning / drug therapy*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Motor Activity
  • Sensation
  • Tissue Extracts / pharmacology*
  • Tissue Extracts / therapeutic use

Substances

  • Biological Products
  • Tissue Extracts